Summary of First Rabies Challenge Results

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Posted June 24, 2015

The first trial in the final challenge phase of The Rabies Challenge Fund research has been completed.  The data yielded mixed results, which are not applicable to our goals of determining the long-term duration of immunity of the rabies vaccine in dogs and establishing a canine rabies titer.

Our challenge was conducted in a USDA-approved facility by a group of researchers using the USDA Title 9 standard for rabies vaccine licensing, upon which The National Association of State Public Health Veterinarian’s Rabies Compendium and state laws are based.  That standard requires that 80% of the control dogs test positive for rabies disease.  Only one (10%) of the 5 control dogs tested positive for disease, while another tested positive for infection.  None of the ten vaccinates tested positive for rabies disease or infection. 

These results show that the challenge virus used by the investigators in this first trial was not virulent enough to cause disease in 80% of the control dogs.

It is our intention to conduct another challenge using a new highly virulent challenge virus from the USDA, which has been successfully used in recent canine rabies trials.

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